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Non-steroidal anti-inflammatory drugs (NSAIDs), statins, glucocorticoids and monoclonal antibodies (e.g., targeting IL-6, TNF-, IL-12/23) have been reported to show moderate anti-depressant capacity in patients with somatic disorders (i.e., rheumatoid arthritis, psoriasis) who also had comorbid symptoms of depression [194, 195]

M.ChhatreD.et al (2009)

As we age, NAD+ levels decline, which can lead to decreased energy, impaired cognitive function, and a higher risk of age-related diseases

In contrast, tumor-promoting immune cells consist mainly of Tregs, myeloid-derived suppressor cells (MDSCs), M2-type macrophages and N2-type neutrophils, which facilitate tumor progression by suppressing antitumor immune responses (17, 18)

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