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It can stress the vascular endothelium (inner lining of blood vessels), leading to dysfunction

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The authors systematically evaluated conflicting findings regarding DSIP's sleep-promoting effects, noting that while initial studies showed dramatic increases in slow-wave sleep, subsequent research produced more variable results depending on species, administration route, and baseline sleep states

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The loading phase typically employs 2 to 2.5 mg twice weekly for four to six weeks, totaling 4 to 5 mg weekly