A physician investigating unexplained hypercobalaminemia will typically order some combination of the following: Complete blood count (CBC) with differential to check for abnormal red blood cell, white blood cell, or platelet counts Liver function tests (ALT, AST, ALP, bilirubin, albumin) to assess liver health Kidney function tests (creatinine, BUN, estimated GFR) to evaluate renal clearance Peripheral blood smear if a myeloproliferative disorder is suspected Abdominal imaging (ultrasound or CT) if liver or abdominal pathology is a concern Cancer-specific markers or screenings if clinical suspicion warrants them The NIH Office of Dietary Supplements fact sheet notes that observational data from a Danish registry analysis of 757,185 people found the adjusted 1-year cancer risk was 1.74 to 4.72 times higher among those with B12 above 813 pg/mL compared to those in the normal range of 203 to 813 pg/mL

It can be used on its own or alongside other therapies when calorie reduction, fatigue, or slow recovery make progress harder to maintain
Its considered the safest choice for both adults and children, regardless of age, gender, ethnicity, or BMI
Theres one exception to this process in terms of absorption: Vitamin B12 (cobalamin)
Many opt to take supplemental B12 alongside a folate supplement to avoid this risk (23, 24)