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Glutamine-derived aspartate induced by GOT2 is transported into the cytosol and converted by GOT1 to oxaloacetate, then converted by malate dehydrogenase (MDH1) into malate and subsequently oxidized into pyruvate by ME1 to create NADPH

10.3389/fmolb.2022.951275 40 ZhengX.JinX.YeF.LiuX.YuB.LiZ.et al (2023)

The synthesis, the function, the consequences of the depletion and the supplementation of glutathione will be presented

231 As will be discussed below, glucose-6-phosphate dehydrogenase deficiency is a common human enzymopathy that leads to several phenotypes ranging from neonatal jaundice to acute anemia, indicating how important NADPH is to prevent oxidative stress in RBCs