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In addition to these mechanisms, oxidative stress activates multiple MAPK pathways, including p38 MAPK, JNK, and ERK1/2

10.1002/ana.20687

Li levels in mouse blood were increased from 6 to 177 g/L with increasing Li exposure doses (156 -fold REED of Li) (Fig

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Moreover, in 230 patients, 99% of those receiving pegaspargase and 95% of those receiving calaspargase and pegol achieved complete remission