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According to the NICE Clinical Knowledge Summary (CKS) and the British National Formulary (BNF) , the standard treatment for B12 deficiency without neurological symptoms involves: Hydroxocobalamin 1 mg intramuscularly three times weekly for two weeks Followed by maintenance doses of 1 mg every three months For patients with neurological symptoms (such as paraesthesia, numbness, cognitive changes, or gait disturbances), more intensive treatment is required: Hydroxocobalamin 1 mg intramuscularly on alternate days until no further improvement occurs Followed by 1 mg every two months for maintenance Pernicious anaemia , an autoimmune condition where the body cannot produce intrinsic factor, requires lifelong treatment

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Mutation Loci of the NPT1 ( SLC17A1 ) Gene The study selects 545 Japanese men with gout as a model group and 1,115 healthy men as a normal control group to investigate mutations in the NPT1 rs1165196 and I269T genes ( rs1165196 variants significantly reduce the risk of renal under excretion gout and enhance the renal urate secretion (Sakiyama et al., 2016)