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Nutrients 8(1):56 Sas K, E Szabo, Vecsei L (2018) Mitochondria, oxidative stress and the kynurenine system, with a focus on ageing and neuroprotection

Hepatic growth hormone receptors respond to circulating HGH, triggering intracellular signalling cascades that upregulate IGF-1 transcription and synthesis

Thats my take on this paper

The supplement can help to boost immunity maintain or improve gastrointestinal health maintain kidney health keep the nervous system functioning optimally keep the pancreas healthy increase appetite It should be given with food

These are not interchangeable. Folic acid is unnatural and problematic : invented in 1945, it requires slow, inefficient conversion through DHFR before your body can use it