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The addition of homocysteine causes some proteins to become pro-inflammatory or pro-thrombotic.[ref] Oxidative stress, ER stress, and mitochondrial dysfunction: High homocysteine levels are also associated with increased oxidative stress, mitochondrial dysfunction, and endoplasmic reticulum (ER) stress

If you do happen to experience a slight headache or any pain, over-the-counter pain meds should help, but should be taken under the guidance of a doctor

What reconstitution approach is standard