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Certainly, early life stressful events such as maternal separation in the rodent, or child abuse/loss of a parent in humans can cause disruption of the HPA axis in this way ( In addition to, or perhaps as a result of, disrupting the HPA axis, the parental influence at this time is also crucial for establishing feeding patterns long-term

Losing weight helps reduce what used to be called non-alcoholic fatty liver disease and is now known as metabolic dysfunction-associated steatotic liver disease or MASLD

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Takeaway: If insomnia is entrenched, CBT-I is foundational