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Second, the cycling recommendation, 8-12 weeks on followed by a 4-week off period, is based on the general principle applied to peptide therapies to prevent receptor desensitization and to allow assessment of lasting effects, rather than on direct MOTS-c cycling data

While these therapies target oxidative cell death and ROS balance in cancer cells, their effectiveness can vary due to factors such as tumor type, stage, and patient-specific characteristics

Molecular Operating Environment (MOE), 2019.01

10.1038/s41591-021-01655-5 30 DicksvedJ.LindbergM.RosenquistM.EnrothH.JanssonJ