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Consequently, a decrease in CHAC1/BOTCH expression levels, caused by the loss of NRF2, rescues NOTCH1 signaling and restores neuronal stem cell self-renewal (Khacho et al., 2016)

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Therefore, to identify the role of NF-B and the regulative mechanism between GPX1 and NF-B in SGNs damage induced by peroxynitrite, we measured the NF-B pathway in SGNs after peroxynitrite administration with GPX1 upregulation or deficiency (Figure 8A)

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