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A long-term follow-up study by MAPS founder Rick Doblin of the Good Friday experiment found that participants appreciation for life and nature was enhanced 24 years after their psilocybin experience, suggesting long-lasting impacts on nature-relatedness

doi: 10.1016/j.freeradbiomed.2010.02.038

These compounds increase SIRT1 expression or activity, collectively improving hepatic lipid metabolism, insulin signaling, oxidative stress, autophagy, and inflammatory responses, highlighting their strong multi-target pharmacological potential