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29 There is also a lack of data on the long-term benefit of oral therapy when patients do not take daily doses

Whilst timing of supplementation is less critical than consistency, factors such as formulation type, food intake, and underlying gastrointestinal health significantly influence absorption efficiency

While topical application has minimal systemic absorption, the precautionary principle suggests avoiding use during pregnancy unless a healthcare provider approves

Regular exercise and a healthy diet are usually recommended for weight loss

However, retatrutide has not received approval from the MHRA or the EMA and remains an investigational agent undergoing Phase 3 trials