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As of June 2026, the FDA's December 2024 Pharmacy Compounding Advisory Committee evaluation concluded that the criteria weighed against placing AOD-9604 (free base) or AOD-9604 acetate on the 503A Bulks List, and AOD-9604 is currently listed as Nominated but Withdrawn from FDA Category 2

Lactating women have higher daily needs for B vitamins (for instance, riboflavin 1.6 mg/day, niacin ~17 mg NE/day), because some of the maternal intake is secreted in milk to nourish the infant

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Tirzepatide with glycine is another common pairing

These include the severity of deficiency, patient age, and malabsorption issues