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76,77 In summary, disc cells respond to altered loads and osmotic pressures, to DAMPs, MMPs and pro-inflammatory cytokines with the expression of catabolic enzymes, with anabolic healing attempts, and with inflammation resulting in failed healing attempts, damage accumulation and chronic inflammation leading eventually to DD
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References: Herrmann W, Obeid R
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This walkthrough answers exactly that a clean bench workflow, the ratio math with worked examples, and how to keep the solution stable once it's mixed
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