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There is a wide variety of polyphenolic compounds, with approximately over 8,000 different types, including common compounds such as apigenin, quercetin, curcumin, anthocyanins, gallic acid, and flavonoids (Jantan et al., 2021

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ALS is mostly diagnosed based on clinical signs, using the revised El Escorial criteria, which require signs of both upper motor neuron (e.g., spasticity, brisk reflexes) and lower motor neuron damage (e.g., muscle wasting, twitching) in multiple body regions (Kwan and Vullaganti, 2022)

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PMID:39057002;PMCID:PMC11275324