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Mice were anesthetized via intraperitoneal injection of ketamine (100 mg per kg body weight) and xylazine (10 mg per kg body weight)

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S2CID 25093505

However, therapeutic doses for treating deficiency range from high-dose oral supplements (1,0002,000 g daily) to intramuscular injections of 1 mg, particularly for pernicious anaemia or malabsorption conditions

Research studies analysing pernicious anemia prevalence across the ICD-9/ICD-10 transition must account for this documentation gap to avoid systematic undercounting