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To our knowledge, this is the first study evaluating the irritancy potential of different types of copper compounds at the cellular, genomic and proteomic levels using keratinocyte cell lines

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Based on hematoxylin and eosin (H&E) staining histological analysis, severe pathological changes (steatosis) were detected in model group mice (Figure 4), as shown by the disarranged liver structure as well as the increased number of vacuoles