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The molecule with the best activity, 84 , proved to be a mixedtype XO inhibitor, and from in vitro tests, exhibited IC 50 values of 0.022 M, equivalent to topiroxostat, the drug used as a positive control (Figure 26)

While cysteine-based approaches are more selective, the reaction is more complicated due to presence of multiple disulfide bonds in the antibody

The amino acid sequence of Tat is YGRKKRRQRRR ( P

Epitalon peptide, also known as epithalon, is a synthetic tetrapeptide made from four amino acids: Ala-Glu-Asp-Gly

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