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Lastly, by incubating the THP1 cells, treated with the peptides, on a layer of activated endothelial cells (HUVECs activated by LPS), we observed a reduction in cell adhesion, a typical pro-inflammatory mechanism

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However, ICV administration of higher doses of GLP- 1 (1 and 3 nmol) and GIP (6 nmol) significantly reduced food intake and body weight