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Most cytokines and their receptors are expressed by neurons and glial cells throughout development, and several studies have revealed that cytokines play important roles in neurogenesis, synapse formation, and plasticity, including IL-1, IL-6, TNF-, TGF-1 and IFN 326,327,328,329,330,331 Cytokines activate several signal transduction pathways, including the Janus kinase-signal transducer and activation of transcription (JAK-STAT) and PI3K/AKT/mTOR pathways, which regulate numerous cellular responses

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Anesthetic Surgery Journal, 44 (1), 60-67

More severe side effects include: Advertisement It can be difficult to diagnose vitamin B12 deficiency because you may not have symptoms, or symptoms can be like other nutritional deficiencies

While the clinical trials demonstrated excellent safety in generally healthy obese adults, individual medical histories may reveal concerns not apparent in trial populations