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In a systematic review, researchers analyzed the gut microbiomes of patients with depression and found substantial differences in microbiome composition compared to healthy individuals, particularly in the abundance of certain bacterial genera, such as Prevotellaceae and Blautia [493, 494]

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These observations suggest that CYP51A1, through its regulation of sterol intermediates such as lanosterol, may modulate the inflammatory signaling landscape in macrophages and indirectly influence pyroptotic sensitivity

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