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While topical application is convenient and non-invasive, the peptide faces a significant barrier: human skin is designed to keep foreign substances out

RGD-GHK significantly promoted the mRNA level of loricrin (LOR) and filaggrin (FLG), which were associated with a marked reduction in the damaged skin barrier

These microorganisms have demonstrated significant potential in providing preventive and therapeutic benefits for allergic conditions, including shellfish allergies [174]

Nature 488, 499503

Theres a rationale behind localized injection: some practitioners use it near a specific treatment area on the theory that proximity might concentrate effects locally