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There was no difference in measures for microglial activation ( p = 0.403) or BBB leakage ( p = 0.423) across the three shells

Hydration and timing matter too

Animal models for dry eye such as desiccating stress and lacrimal gland excision and cataract including selenite- or steroid-induced forms are well-established

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So there's some hardwiring of preference, but there's also some soft-wiring in the system that allows it to change