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The gap between the internet narrative and the published science is one of the largest in peptide research

Activation of Caspase-8 promotes Caspase-3-mediated apoptosis (Legembre et al., 2002), while inhibiting the RIPK1/RIPK3 axis (necroptosis) (Newton and Manning, 2016) and the NLRP3/Caspase-1 axis (pyroptosis) (Frank and Vince, 2019)

[DOI] [PMC free article] [PubMed] [Google Scholar] Tong J., Fitzmaurice P.S., Moszczynska A., Mattina K., Ang L.-C., Boileau I., Furukawa Y., Sailasuta N., Kish S.J