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Psoriatic skin lesions can appear as much as two decades before the onset of arthritis

Oral bioavailability is expected to be negligible given the peptide's large size, and subcutaneous or intravenous delivery would likely be required for any human application

The N-acetylated amidated structure allows researchers to investigate these pathways with improved molecular stability and consistency across experimental models

Bernd Coester: Data analysis and interpretation, writingoriginal draft

Important considerations include: neither peptide has received broad regulatory approval for routine therapeutic use in major jurisdictions