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The direct, quantified, longitudinal human measurements that would settle it are largely absent from the published cagrilintide monotherapy literature, and there is a credible mechanistic reason the tendency of long-acting gut-hormone agonists toward gastric-emptying tachyphylaxis, plus obesity-associated amylin-receptor down-regulation to suspect the gastric arm may attenuate even as central satiety persists

PLoS Clin

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If restrictions are eased, the peptides could then be prepared and sold as compounded medications with a prescription by pharmacies in the United States

(8) Wu D, Lee D, Sung YK