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10.3390/ijms18112454 251 SummaJ.Von HoffD.SachdevJ.MitaM.LoRussoP.EisenbergP.et al (2015)

ISSN 1929-0748

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8 Humans with mutations in the IR (Leprechaunism) exhibit profound growth retardation, 9 which resembles those seen in mice with engineered mutations of the IR

Metabolic levels associated with MTX resistance In addition to the association between metabolic fold change and MTX resistance, we searched for correlations between metabolic concentration and resistance to MTX (expressed as IC50) at 48 and 96 hours in either the presence or absence of the drug ( Table 1 )