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These results are backed up by the finding of a strong increase of the concentration of Pycnogenol s metabolites and components in the synovial fluid, surrounding articular cartilage in the joints in osteoarthritis patients ( intake in osteoarthritis patients reduced gene expression of key catabolic and inflammation markers like MMP-3, MMP-13 and IL-1 by more than 50% within knee cartilage ( contributes to restoring health in damaged joints

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IGF-1 elevation: Sustained GH elevation raises IGF-1

Oncogene 23 , 28382849 (2004)