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Indications eye drops Directions Add 1-2 drops of DMSO eyes to the affected eye 2-3 times a day

Non-electrophilic compounds Also known as KEAP1-NRF2 protein-protein interaction (PPI) inhibitors, they comprise several classes of compounds, including naphthalene bis-sulfonamides, tetrahydroisoquinolines, and molecules that present an oxadiazole motif [66]

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Damage to the BBB typically occurs within minutes to hours following the injury and involves generation of reactive oxygen species and the activation of matrix metalloproteases (MMPs), such as MMP-2, MMP-3 and MMP-9 and MMP-12 that degrade the basement membrane, tight junction proteins and damage cellular components of the neurovascular unit, such as pericytes