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This study describes a mechanism by which CTLA4 blockade contributes to loss of T reg cell stability in tumours

In our study, strong HGF induction of phosphorylation was readily detectable in a number of specific phosphorylation sites in phosphoproteins, downstream of c-MET itself, that are involved in c-MET/HGF signal transduction in SCLC NCI-H69 cells (Figures 2A and B)

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doi: 10.1590/1806-9282.66.s1.3