achieved rapid isolation of target compound senkyunolide-I and byproduct ferulic acid from Ligusticum chuanxiong 's 95% (v/v) ethanol extract using RP-HPLC with ammonium acetate as modifier, employing step gradient elution and resin column desalination, yielding purities exceeding 98% ( 4 Anti-migraine mechanisms of senkyunolides As a complex neurological disorder, migraine pathogenesis involves multifaceted mechanisms centered on abnormal activation of the trigeminovascular system, which triggers the release of neuropeptides, subsequently inducing neurogenic inflammation and central sensitization
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Compared with patients with normal nucleus pulposus, patients with lumbar disc herniation presented higher haemoglobin concentrations in the disc nucleus pulposus, a higher quantity of dark iron particles following staining, and elevated expression levels of HO-1 (177)
