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Kassis ES, Vaporciyan AA, Swisher SG, Correa AM, Bekele N, Erasmus JJ, Hofstetter WL, Komaki R, Mehran RJ, Moran CA, Pisters KM, Rice DC , Walsh GL, Roth JA

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The response to oxidative stress is mainly regulated by the mitochondria of RGCs and their axons [399]

348 The role of the UPS in NDDs The ubiquitinproteasome system (UPS) represents a highly coordinated protein quality-control network responsible for selectively tagging, recognizing, and degrading damaged, misfolded, or excess proteins through ubiquitination