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BCR-ABL encodes a constitutively active tyrosine kinase that phosphorylates a panel of downstream targets to cause uncontrolled cell proliferation, protein synthesis, and anti-apoptotic signals 3,4,5,6

They act as biological messengers in the body, helping regulate vital processes like hormone release, inflammation, growth, metabolism, and cellular repair

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Cartilage & Joint Research Kwon and Park, Annals of Clinical and Laboratory Science (2015) Kwon and Park investigated the chondroprotective effects of intra-articular AOD-9604 administration in a rabbit model of osteoarthritis, with and without co-administration of hyaluronic acid