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We established that Fbx2 overexpression in primary neurons derived from Tg2576 transgenic mice, a well characterized AD mouse model (Hsiao et al., in vivo studies with Tg2576 mice, we found that stereotactic delivery of adenoviral-Fbx2 to the brain significantly increased Fbx2 expression and decreased synaptic deficits coinciding with a reduction of BACE1, which is essential for A formation (Gong et al., 2005

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