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Description

However, UBXD8, a protein in the ER-associated degradation (ERAD) pathway, can bind PNPLA2, preventing the interaction with ABHD5, thereby segregating PNPLA2 to valosin-containing protein (VCP)/p97 segragrase that promotes extraction and subsequent Ub-dependent degradation (132) (Figure 1)

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By week 4, many of these patients have moved from significant functional impairment from GI symptoms to largely resolved or substantially reduced symptom burden

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The symptoms distinguish themselves through temperature shifts in the arm, visible skin changes and severe pain that increases with even light contact

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