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[12] What little has appeared since is preclinical and mostly concerns engineered analogues rather than DSIP itself for instance, fusion constructs designed to survive in circulation and cross the blood-brain barrier, tested in chemically-induced insomnia models in mice

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coli proB , and the resulting strains were W303-1b/gsh1 ( GSH1 deletion), W303-1b/gsh1/pro1 ( GSH1::P gap - PRO1 - T pgk1 ) and W303-1b/gsh1/proB ( GSH1::P gap - proB - T pgk1 ) (Table 2)