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These situations affect only a small number of people

The pivotal mouse study used subcutaneous injection, not oral dosing a real mismatch between the tested route and typical community/commercial use

Reconstitution math for the 50 mg 5-Amino-1MQ vial BAC water added 1.0 mL Concentration 50.0 mg/mL 1 unit (U-100) equals 0.50 mg (500 mcg) BAC water added 2.0 mL Concentration 25.0 mg/mL 1 unit (U-100) equals 0.25 mg (250 mcg) BAC water added 3.0 mL Concentration 16.7 mg/mL 1 unit (U-100) equals 0.167 mg (167 mcg) Use 3.0 mL as the maximum BAC-water volume for this 50 mg vial format

Drug approval requires demonstrated efficacy plus safety

Vitamin B12 contributes to Energy yielding metabolism Functioning of the nervous system Red blood cell formation Homocysteine metabolism Psychological function Functioning of the immune system Vitamin B12 also plays a role in the process of cell division and the reduction of tiredness and fatigue