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This study describes a novel biochemical mechanism by which glutathione deficiency causes epigenetic impairment of vitamin D metabolism gene in the liver and its contribution to reduced circulating levels of 25(OH)VD 3 in HFD-fed obese mice

Gene ontology of genes in the NRF2 cistrome that were also upregulated by BDG exposure were enriched for the biological processes: response to oxidative stress, cell-cell adhesion, cytokine signaling, and glutathione metabolism ( Figure 3D and Supplementary Table 5B )

GSH is also essential for the glyoxalase system, which contributes to the detoxification of reactive dialdehydes and is utilized during protein glutathionylation, which is a crucial step in the post-translational regulation of protein metabolism (97)

Restorative sleep supports antioxidant defenses, including glutathione, while chronic sleep loss has been linked to lower glutathione activity

Known as the bodys "master antioxidant", Glutathione is naturally produced to support various biological processes