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Science 224:569573

Best peptides for dark circles and their specific mechanisms Copper peptides , particularly GHK-Cu , prove highly effective for vascular dark circles through collagen type I and III synthesis dramatically thickening delicate periorbital skin, copper delivery supporting lysyl oxidase enzyme creating stable collagen cross-links strengthening dermal structure, and anti-inflammatory effects reducing chronic irritation contributing to both vascular dilation and melanin production

Deeper benefits, like immune support or antioxidant protection, accumulate gradually and may take longer to notice

\(wt\) stands for the UPDRS score of patients under treatment

Calcif Tissue Int 60(4):375379