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Mitchell LL, Albers EA, Birkeland RW, et al

In a cohort of pregnant women in Bangalore, India, with a high incidence of vitamin B-12 deficiency, we reported previously that women in the lowest tertile for plasma vitamin B-12 concentration during all 3 trimesters of pregnancy had significantly higher risk of IUGR that persisted after adjusting for maternal age, weight, education, and parity (12)

Rather than measuring B12 directly, the MR used 8 genetic variants (SNPs) known to raise B12 levels as a proxy for lifelong B12 levels

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