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This phenomenon is not restricted to tumor cells but is also manifests itself in a variety of non-neoplastic pathological conditions, such as pulmonary vascular remodeling, cardiac hypertrophy, and multiple sclerosis, and its metabolic inhibitors have shown potential for therapeutic use

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This can be countered by following a programme consisting of an anti-inflammatory diet and cosmeceuticals

Increasing evidence supports a role for altered metabolism in the tumour response to treatment ( Metformin, which is approved clinically for the management of type II diabetes, has an elusive precise mechanism of action, however, it has been demonstrated to inhibit complex I of the ETC ( in vitro and in xenograft models of colon cancer ( In this study, SW837 rectal cancer cells, and HCT116 colon cancer cells were utilised as an in vitro model of inherently radioresistant, and radiosensitive CRC, respectively

91st Annual Meeting American Association for Thoracic Surgery:89, 2011