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In the early twentieth century, work moved on to the investigation of the enzymes and pathways that were responsible for the production of these metabolites

The adrenal glands use steroids such as cholesterol (which is involved in the production of hormones such as progesterone, estrogen, testosterone, DHEA, and aldosterone) to make hormones

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Its mechanisms include modulation of neurotransmitter signaling that promotes slow-wave activity, reduction of nighttime cortisol and stress hormone interference with sleep architecture, and support for the timing and depth of the sleep cycle itself