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In order to be taken up by the liver it has to be degraded to amino acids. [I also wonder- since glutamate is elevated in metabolic disease, and a residue in the GSH tripeptide, might it be that providing glycine or serine to support synthesis could be preferred over glutathione

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The EU's Scientific Committee on Consumer Products (SCCP) found very low skin penetration in human skin tests and negative results for irritation, phototoxicity, and photoallergy