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Neurogenic inflammation in acute migraine attacks is characterized by a TVS activation-induced release of neuropeptides, such as CGRP and substance P, from trigeminal nerve fibers at the dura, which causes increased vascular permeability, plasma protein extravasation, leukocyte infiltration, vasodilation, mast cell degranulation, activation of meningeal nociceptors, and the subsequent release of inflammatory mediators (5)

These transitions of actively proliferating cells to dormant state happen repeatedly during morphogenesis

The conservative approach is to avoid the combination entirely

doi: 10.1534/genetics.117.201491 106 Navarro-GarciaF.SanchezM.NombelaC.PlaJ