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Current and daily smoking prevalence among 15-24 year olds reduced steadily from 2011/12 to 2019/20 (current and daily smoking declined about 1.1% per annum on average during this period)

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These increased inflammatory factors and chemokines leads to further infiltration of immune cells into the respiratory tract, resulting in dysfunctions of fibroblasts, goblet cells, and epithelial cells, ultimately leading to emphysema, mucus accumulation, inflammation, and pulmonary fibrosis [52]