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The absence of drug affinity complex modification results in a shorter receptor interaction window, allowing for transient activation that aligns with pulsatile signaling models

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Sulfation (30-35%) - SAFE Safe elimination pathway DECREASES by 33% during pregnancy Limited capacityeasily saturated with higher or repeated doses Predominant pathway in fetuses/children but quickly overwhelmed 3

This can reflect the downstream effects of chronic microglial activation and dysregulated blood-brain barrier permeability