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A June 2004 study found that NRT clinical trials were generally not blind as claimed in that "subjects accurately judged treatment assignment at a rate significantly above chance." If clinical trial participants could tell whether or not their nicotine gum or lozenge was delivering nicotine or was instead an empty placebo, it could explain why NRT efficacy is so high in clinical trials yet falls flat on its face the moment it exits the trial clinic's doors

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Gostin: Regulations should prompt smokers to switch Vaughan Rees: Finding the regulatory sweet spot will save lives By Sue Curry: While we await evidence about the balance of benefits and risks of electronic cigarettes, we already know that their use is increasing among youths and that it leads some of them to start smoking combustible cigarettes

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