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With increasing age, however, forming new memories becomes less efficient, due to a largely unknown etiology

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First, current biomarkers (such as serum GPX4) are derived from mouse controlled cortical impact (CCI) models, yet the pathological heterogeneity of human TBI far exceeds that of animal models, making these biomarkers inadequate for guiding clinical treatment

Actually, glutamine-derived -ketoglutarate is a co-substrate of dioxygenase enzymes, including the TET family and the jumonji (JMJ) family