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The biomarkers associated with an increased risk of cardiovascular events include fibrinogen and endothelial dysfunction, as well as the cytokines IFN- and TNF-, and these two inflammatory markers have also been shown to be predictive of future cardiovascular events [28]

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7 These pretreatment doses and times were selected based on other previous studies 1 , 7 and preliminary experiments in which the safety after injection was determined, since we used rats as the experimental animals

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